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DHT, as it commonly abbreviated, is a sex steroid and an androgen (associated with masculine characteristics) hormone. The enzyme (a substance produced by the body to help bring about a biochemical reaction) called 5α-reductase synthesises DHT from testosterone in areas like the prostate and hair follicles, as well as the testes and adrenal glands. Essentially DHT is made from testosterone and helps the body grow and regulate itself.

What does DHT do?

DHT is involved in maintaining and developing sexual characteristics as well as metabolic activities such as the production of blood cells. So for men, DHT is an essential part of puberty that can quickly sour in the minds of many when experiencing thinning or balding on the scalp

DHT inhibits and reduces the proper growth of hair in the follicles in a process called ‘miniaturisation’. ‘Miniaturisation’ affects genetically-susceptible hair follicles resulting in lighter, finer hairs. DHT attaches itself to receptor cells of the part of these follicles called dermal papillas (the root), preventing the necessary nourishment for the hair getting through for proper growth. DHT causes the hair follicles to shrink. The growing ‘anagen’ stage of the hair is shortened and the resting ‘telogen’ stage is extended. Eventually these hairs stop growing.

Male pattern baldness, or androgenic alopecia, typically affects the front and top of the scalp first where the most genetically-susceptible hair follicles reside. DHT is the primary contributing factor in male pattern baldness. Female hair loss can be very complicated and DHT could be just one of the possible causes. In women DHT is influenced by a decrease in oestrogen and hair loss tends to result in thinning, rather than complete balding.

What can I do?

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